Hemangiosarcoma (HSA) is a rapidly growing, highly invasive cancer arising from the lining of blood vessels. Even with a splenectomy and chemotherapy, dogs with HSA rarely live longer than 6 months. This paper describes the current treatment options for HSA, which are not very effective and do little to prolong your dog's life.
Dexter, who is six years old, was diagnosed with HSA and had a splenectomy in October, 2019. Dexter was given 3 months to live.
Dexter is alive because his owner did everything right - he had the HSA tumor removed with a splenectomy and started on GDF11 right away.
18 Months later and Dexter is cancer free, healthy and energetic. And he may well the oldest living HSA dog on the planet.
The mechanism of action of HSA reversal is most likely GDF11's increasing endothelial repair as well as GDF11 targeting and reducing mitochondrial function of HSA tumor cells. Which either kills tumor cells or at least stops replication.
You can read Dexter's HSA and GDF11 history here.
Fifty is a 14 year old German Shepard who collapsed at the vet from HSA on May 3, 2020. Soon after he collapsed, Fifty had an emergency splenectomy.
After only a month on GDF11, Fifty returned to the vet for follow up exams. You can read all of the vet reports here.
Note that after only a month on GDF11, Fifty was cancer free and remains cancer free to this day.
Fifty is now back to his old self and has plenty of energy for a 14 year old dog.
We cannot emphasize enough how important it is to start on GDF11 right after your dog's HSA diagnosis. Hemangiosarcoma is like a California wildfire - it is very aggressive and spreads rapidly. GDF11 does very well at eradicating HSA if you start early.
Also, having the HSA tumor removed through splenectomy or other surgery gives GDF11 more of a fighting chance against any HSA that remains post surgery.
Bella is a longhaired dachshund born November 5, 2008.
Bella had a splenectomy on September 3rd, 2020 and HSA was suspicioned. Liver biopsy was taken as well which came back benign. Spleen tumor came back malignant and confirmed HSA diagnosis.
Bella started on GDF11 on October 6, 2020. Her Dog Mom writes that Bella is back to chasing squirrels, something she hasn't done in years. She also has been scoring perfect 10's in her subjective biomarkers of energy, appetite gums and eyes.
Bella also now has very strong Emfit biomarkers often showing HRV of 150+, pulse of 55 and breaths per minute of 12.
Once again, Bella's owner moved quickly and decisively on GDF11 supplementation and that's why she's doing so well today.
Leo is a Golden Retriever born on 12/14/2010.
On the evening of 10/26/2020 Leo seemed as if he were about to faint. We took him to the Emergency Vet Hospital. Dr. put a syringe in his abdomen and got blood. She suspected HSA and said he needed emergency surgery. He had a splenectomy that night, stayed in the hospital a couple days and came home to recuperate.
The spleen biopsy was positive for HSA, but liver nodules resulted benign.His mitotic score was a 2. His stitches were removed 2 weeks after surgery. We took him off all dog food and switched his diet to ground meat with low glycemic veggies and added Turkey Tail mushroom powder and also starting him on Reishi mushroom powder.
Leo started on GDF11 on 11/19/20 and the changes were dramatic - after all GDF11 is the master regulator of vertebrate aging.
Leo's Dog Mom gives him all 10's in the subjective biomarkers of appetite, energy, gums and eyes. And Leo also has very solid Emfit biomarkers of HRV, pulse, breaths per minute, % deep sleep, etc.
And of course, no signs of any more bleeds. As long as his biomarkers hold up, future bleeds unlikely.
Rocko is an American Bulldog born on January 1st, 2009.
Rocko had a splenectomy in December 2019, and his spleen was full of tumors. The vet confirmed it was HSA but he didn’t recommend anything else to prevent further spread because he has said he got it all.
Fast forward to October 22, 2020, and Rocko had his first bleed. It was big, his belly was extremely distended, and he didn’t want to move or eat. Vet did scans and he had a tumor by his chest, and he showed signs of some damage to his right kidney but otherwise bloodwork showed to be “normal”.
Rocko started on GDF11 on 12/8/20 and things turned around rapidly.
His Emfits now show a solid breaths per minute of 9, pulse of 72 and a strong HRV RMSSD of 159. Note that during a bleed, pulse and breaths per minute will skyrocket and HRV will plummet.
Between the GDF11 and the Emfit biomarkers we are keeping HSA at bay and have probably eradicated it in a few cases.
Luna started showing lethargy 3 months ago (~10/15/2020) and we thought it was older age and arthritis because of the breed’s predisposition to hip issues in advanced age.
On 1/27/21 we observed Luna having difficulty getting up and shivering from discomfort. Called vet and brought her in next day. Vet used ultrasound to look at abdomen as vet observed the malaise in Luna’s disposition and a distended abdomen. She viewed a very large mass and build up fluid in ultrasound and suspected that it was HSA, as the mass was appearing to be stemming from the spleen.
After conversation with me, and discussing the symptoms, they advised to euthanize before she crashes as it appeared she was in an active bleed but it was a “slow bleed into the abdominal cavity.” Vet advised against surgery because the expected survival rate wouldn’t be worth it, and would not provide a great quality of life with chemotherapy etc., and, the vet offered a referral to a surgeon if we so choose, as her clinic (Banfield chain) does not perform surgeries any longer.
After discovering GDF11Rejueination, applying and hearing back from Steve Perry on 1/29/21, Steve made it clear that GDF11 + splenectomy would give Luna the best chance at recovery from HSA, and I scheduled splenectomy for same day. Diagnosis date: 1/28/21 splenectomy date: 1/29/21 Approximate Tumor size per surgeon verbally of “2-3 tennis balls”. It was rather large. I have yet to get the exact measurement but I can say post surgery her abdomen appears substantially smaller.
Since starting her on GDF11 on 2/2/21:Luna’s energy is way up today, and her appetite is awesome! She’s eating her food now and then some. Keeps asking for more food throughout the day and is eating it all up. She definitely has more energy than I’ve ever seen her have. Ever. We’ve had her for 4.5 years and she never had energy past 7pm and now I am finding myself not stimulating her enough which is crazy in a fantastic way.
This is all very encouraging and she has never acted healthier. We walked an extra block today without her really losing her energy or excitement. Hang in there everyone!
Zadie is an eleven-year-old Australian Shepard mixed breed that we adopted when she was seven months old.
On October 14, 2020, she became extremely lethargic and could barely walk. We carried her immediately to her veterinarian and she had to be carried into their office on a stretcher. The vet said that Zadie had a large tumor that had ruptured and that she was bleeding internally. She said that Zadie could only live a few hours and suggested that we have her euthanized immediately.
I asked to see her x-rays and the vet pointed out that the tumor was in her spleen and was impinging on her heart and lungs. She again suggested euthanasia. She explained that the tumor needed to be removed but opined that Zadie would not survive surgery.
She again said that she needed to be euthanized. I refused and she gave me a package of Yunnan Baiyao and some liquid prednisone. I took her home and she improved, and I began to think that she might successfully undergo surgery.
On November 20, 2020, I took her to Wilmington, N. C. for an ultrasound. That revealed that the bleeding had stopped, and no metastases was seen. On November 25, 2020, she had a splenectomy at Points East Vet Specialty Hospital in Wilson, N.C. The biopsy was positive for hemangiosarcoma in the spleen but negative in the liver. For two days she was unable to stand but slowly recovered. On December 9, 2020, her stitches were removed, and I had my vet employ Fido cure for genome testing.
Over a month later, they issued a report that indicated that Zadie had a mutation of the P53 gene that would significantly impact reducing response to chemotherapy” and that dogs with P53 mutation “had significantly shorter overall survival duration than dogs without P53 mutation.” Notwithstanding, they recommended traditional chemotherapy and two human chemotherapies, all with toxic side effects, including nausea, vomiting, diarrhea, hair loss and skin problems.
At this point I began to look for an alternate treatment therapy. That is when I discovered Steve Perry’s GDF11 web site. After researching GDF11, I called Steve and he quickly arranged for me to acquire GDF11 and an Emfit. She had her first dose on January 22, 2021.
Since then, her dosage has been reduced three times and her Emfit readings have been excellent. In February 2021, I took her back to the vet for blood testing. The vet told me she was amazed at Zadie’s blood test. She said everything was completely normal except the test relating to the loss of her spleen. She gave me a copy of the October 2020 test and the February 2021 test so I could see the difference. She also x-rayed Zadie and the -x-ray was also normal.
On March 8, 2021 I had my vet send Zadie’s blood plasma to Texas A and M University for nucleosome testing to see if she still had hemangiosarcoma... Her test results showed that she had a nucleosome reading of 29 ng/ml. The report said, “Plasma nucleosome concentrations ranging below 57.4 ng/ml are consistent with those found in healthy animals of all genders over the age of 1 year.”
I have done a lot of research on GDF11 and I am convinced that it is indeed a cure for hemangiosarcoma. My dog is well and has suffered no side effects from GDF11 except she has gotten a little pudgy from eating so much. I am so glad I opted for this treatment instead of chemotherapy. I don’t think if I had chosen the latter that she would still be alive now and if she was, would have had a miserable few months of illness.
Anyone is welcome to contact me at email@example.com and I will furnish you a copy of the various reports on Zadie.
Interestingly enough, GDF11 has gone the opposite route of most peptides/drugs. It has been tested in humans for over 6 years and is fairly well understood. Only when a GDF11er gave some GDF11 to his dog Dexter (see above) did we learn that GDF11 can cure HSA!
Getting your dog going on GDF11 is a relatively simple process. Please start by printing, signing, scanning and emailing to us our standard release form.
We will then do an allometric analysis to determine your dog's optimal starting dose. We then send you a biomarker trending/dosing spreadsheet which you fill out when you dose your dog with GDF11.
Based on trending of your dog's heart rate variability, breaths per minute, pulse, etc., (which is measured nightly by an Emfit placed under his/her bed) we adjust the dose for optimal efficacy.
To cover our overhead, biomarker analysts and R&D expenses, we normally charge humans $15,000 for biomarker/dosing analysis.
Not surprisingly, HSA/lymphoma dogs often require much more biomarker analysis / dosing calls than humans do. But we love our dogs and cats and are willing to take a loss on our work to save our best friends. Therefore our fee for HSA dogs is only $3000.
We would appreciate it if you pay the $3000 fee up front. If you are not comfortable with this, you can pay the $3000 within 3 months of signing the agreement. If your dog passes away during the first 3 months, you owe us nothing.
We ask that you purchase the Emfit and GDF11 yourself. The Emfit is $250 and GDF11 is about $350.
If things do not work out, it is usually easy to resell Emfits/GDF11 on our Slack community since both are in short supply. We look forward to helping you with your HSA/lymphoma dog.
GDF11 is an endogenous (meaning it's natural and you have it in you) signaling molecule whose main mechanism of action is stem cell DNA repair.
Most of aging is likely caused by the atrophy of your stem cell populations due to declining GDF11 levels and many believe this is natural selection's way of programming lifespan.
GDF11 also has been shown to target cells with stem cell like qualities. All cancer cells exhibit "stemness" and GDF11 binds to tumor cells, disables mitochondrial function and kills them. Note that we have had success with dog lymphoma also as well as feline MCT. You can read more about this here.
Additionally, activating senescent stem cells, especially mesenchymal stem cells, results in increased endothelial repair and this is most likely another part of how GDF11 cures HSA.
And here is a fascinating fact about GDF11 - it's molecular structure is conserved across all vertebrate species. Which means human, dog, cat and even orangutan GDF11 are identical.
This strongly suggests how important GDF11 is to life.
Click here to learn more about this fascinating molecule!
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Lifespan is programmed by natural selection based on a species' resources, predation and the stability of their environment.