Hemangiosarcoma (HSA) is a rapidly growing, highly invasive cancer arising from the lining of blood vessels. Even with a splenectomy and chemotherapy, dogs with HSA rarely live longer than 6 months. This paper describes the current treatment options for HSA, which are not very effective and do little to prolong your dog's life.
Dexter, who is six years old, was diagnosed with HSA and had a splenectomy in October, 2019. Dexter was given 3 months to live.
Dexter is alive because his owner did everything right - he had the HSA tumor removed with a splenectomy and started on GDF11 right away.
15 Months later and Dexter is cancer free, healthy and energetic.
The mechanism of action of HSA reversal is most likely GDF11's increasing endothelial repair as well as GDF11 targeting and reducing mitochondrial function of HSA tumor cells. Which either kills tumor cells or at least stops replication.
You can read Dexter's HSA and GDF11 history here.
Fifty is a 14 year old German Shepard who collapsed at the vet from HSA on May 3, 2020. Soon after he collapsed, Fifty had an emergency splenectomy.
After only a month on GDF11, Fifty returned to the vet for follow up exams. You can read all of the vet reports here.
Note that after only a month on GDF11, Fifty was cancer free and remains cancer free to this day.
Fifty is now back to his old self and has plenty of energy for a 14 year old dog.
We cannot emphasize enough how important it is to start on GDF11 right after your dog's HSA diagnosis. Hemangiosarcoma is like a California wildfire - it is very aggressive and spreads rapidly. GDF11 does very well at eradicating HSA if you start early.
Also, having the HSA tumor removed through splenectomy or other surgery gives GDF11 more of a fighting chance against any HSA that remains post surgery.
Bella is a longhaired dachshund born November 5, 2008.
Bella had a splenectomy on September 3rd, 2020 and HSA was suspicioned. Liver biopsy was taken as well which came back benign. Spleen tumor came back malignant and confirmed HSA diagnosis.
Bella started on GDF11 on October 6, 2020. Her Dog Mom writes that Bella is back to chasing squirrels, something she hasn't done in years. She also has been scoring perfect 10's in her subjective biomarkers of energy, appetite gums and eyes.
Bella also now has very strong Emfit biomarkers often showing HRV of 150+, pulse of 55 and breaths per minute of 12.
Once again, Bella's owner moved quickly and decisively on GDF11 supplementation and that's why she's doing so well today.
Leo is a Golden Retriever born on 12/14/2010.
On the evening of 10/26/2020 Leo seemed as if he were about to faint. We took him to the Emergency Vet Hospital. Dr. put a syringe in his abdomen and got blood. She suspected HSA and said he needed emergency surgery. He had a splenectomy that night, stayed in the hospital a couple days and came home to recuperate.
The spleen biopsy was positive for HSA, but liver nodules resulted benign.His mitotic score was a 2. His stitches were removed 2 weeks after surgery. We took him off all dog food and switched his diet to ground meat with low glycemic veggies and added Turkey Tail mushroom powder and also starting him on Reishi mushroom powder.
Leo started on GDF11 on 11/19/20 and the changes were dramatic - after all GDF11 is the master regulator of vertebrate aging.
Leo's Dog Mom gives him all 10's in the subjective biomarkers of appetite, energy, gums and eyes. And Leo also has very solid Emfit biomarkers of HRV, pulse, breaths per minute, % deep sleep, etc.
And of course, no signs of any more bleeds. As long as his biomarkers hold up, future bleeds unlikely.
Rocko is an American Bulldog born on January 1st, 2009.
Rocko had a splenectomy in December 2019, and his spleen was full of tumors. The vet confirmed it was HSA but he didn’t recommend anything else to prevent further spread because he has said he got it all.
Fast forward to October 22, 2020, and Rocko had his first bleed. It was big, his belly was extremely distended, and he didn’t want to move or eat. Vet did scans and he had a tumor by his chest, and he showed signs of some damage to his right kidney but otherwise bloodwork showed to be “normal”.
Rocko started on GDF11 on 12/8/20 and things turned around rapidly.
His Emfits now show a solid breaths per minute of 9, pulse of 72 and a strong HRV RMSSD of 159. Note that during a bleed, pulse and breaths per minute will skyrocket and HRV will plummet.
Between the GDF11 and the Emfit biomarkers we are keeping HSA at bay and have probably eradicated it in a few cases.
Interestingly enough, GDF11 has gone the opposite route of most peptides/drugs. It has been tested in humans for over 6 years and is fairly well understood. Only when a GDF11er gave some GDF11 to his dog Dexter (see above) did we learn that GDF11 can cure HSA!
Getting your dog going on GDF11 is a relatively simple process. Please start by printing, signing, scanning and emailing to us our standard release form.
We will then do an allometric analysis to determine your dog's optimal starting dose. We then send you a biomarker trending/dosing spreadsheet which you fill out when you dose your dog with GDF11.
Based on trending of your dog's heart rate variability and pulse, which is measured by an Emfit placed under his/her bed, we adjust the dose for optimal efficacy.
To cover our overhead and R&D expenses, we normally charge humans $15,000 for biomarker/dosing analysis.
We will be charging $3000 for HSA dogs starting March 1st, 2021, We are providing our services free of charge until then.
Since we are performing our services gratis, we ask that you purchase the Emfit and GDF11 yourself. The Emfit is $250 and GDF11 is about $300.
We look forward to helping you with your HSA dog.
GDF11 is an endogenous (meaning it's natural and you have it in you) signalling molecule whose main mechanism of action is stem cell DNA repair.
Most of aging is likely caused by the atrophy of your stem cell populations due to declining GDF11 levels and many believe this is natural selection's way of programming lifespan.
Activating senescent stem cells, especially mesenchymal stem cells, results in increased endothelial repair and this is most likely part of how GDF11 cures HSA.
Additionally, GDF11 has been shown to target cells with stem cell like qualities, which is another reason it is effective against HSA. All cancer cells exhibit "stemness" and GDF11 binds to tumor cells, disables mitochondrial function and kills them. Note that we have had success with dog lymphoma also. You can read more about this here.
And here is a fascinating fact about GDF11 - it's molecular structure is conserved across all vertebrate species. Which means human, dog, cat and even orangutan GDF11 are identical.
This strongly suggests how important GDF11 is to life.
Click here to learn more about this fascinating molecule!
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Lifespan is programmed by natural selection based on a species' resources, predation and the stability of their environment.