GDF11 and Klotho, both endogenous peptides, make for an exceptional anti aging combination. GDF11 addresses stem cell atrophy by repairing cell DNA. Klotho works on FGF21 pathways to improve insulin resistance, which usually results in weight loss, as well as improved skin elasticity.
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Lifespan is programmed by natural selection based on a species resources, predation and the stability of their environment.