GDF11 and Klotho, both endogenous peptides, make for an exceptional anti aging combination.
GDF11 addresses stem cell atrophy by repairing and reactivating senescent hematopoietic, mesenchymal, endothelial and other stem cells. GDF11 also has powerful anti tumor capabilities and has cured dozens of dogs of hemangiosarcoma, lymphoma, lung and other cancers.
Klotho works on FGF21 pathways to improve insulin resistance and skin elasticity. It has also been shown to improve cognition as per this recent Journal of Nature paper.
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Lifespan is programmed by natural selection based on a species resources, predation and the stability of their environment.