GDF11 is an endogenous (meaning it's natural and you have it in you) signalling molecule whose main mechanism of action is stem cell DNA repair and tumor surveillance/eradication.
Most of aging is likely caused by the atrophy of your stem cell populations due to declining GDF11. It was recently discovered that GDF11 levels fall to zero at a mean age of 73.71. Zero GDF11 means no stem cell DNA repair which causes stem cells to die off at an even faster rate. This suggests that GDF11 may play a key role in maximum lifespan determination.
Fortunately, adding exogenous GDF11 can generally repair enough of senescent stem cells to reverse your age 5 to 10 years. And we have biomarker evidence to support this.
Not only do we have biomarkers suggesting GDF11 can take you back at least 10 years, we also have data showing that it can greatly slow aging as long as you continue to replace your GDF11 that is lost over time. As per the GDF11 Paper, you only need to replace 10 picograms per month, if that.
GDF11's strongest suits are cardiac, neural, skin and endothelial repair. As well as binding to and neutralizing cancer tumor cells.
Cardiac repair is shown by increased HRV as well as lower blood pressure, pulse and augmentation pressure/index biomarkers.
GDF11 significantly reduces reaction time by an average of 13%. Reaction time is guaranteed to increase linearly with age, and reducing it is a feat that has never been accomplished by any substance or peptide. MOA is GDF11 increasing blood flow to the brain through increased vascularization.
Endothelial repair, which refers to the repair of the linings of your blood vessels, is another strength of GDF11. This results in increased blood flow to all organs, especially the brain. This is why GDF11 can significantly reduce arterial plaque.
Other improvements from GDF11 supplementation include improved skin elasticity, spirometry (lung function), kidney and liver function.
GDF11 also reactivates HOX genes which control the shape of our organs, hence its ability to reverse BPH and cardio hypertrophy.
Even more exciting, recent research has discovered that GDF11 binds to cells with stem cell like qualities, and therefore binds to cancerous tumor cells and disables their mitochondrial function. This why GDF11 has been able to reverse/cure canine hemangiosarcoma and lymphoma.
Since all tumor cells exhibit "stemness", odds are GDF11 will be effective against human cancers also and we look forward to human GDF11 cancer trials in the near future.
By the way, that beautiful "squiggle" at the top of this page is the structure of the GDF11 molecule as well as our logo. It's the largest cytokine in the human body weighing in at 45,091 Daltons. GDF11 is almost 8 times the size of insulin and therefore needs to be injected. GDF11 injections take only a few seconds per day to administer.
A fascinating fact about GDF11 is that its structure is conserved across all vertebrate species e.g., cat, mouse and human GDF11 are all exactly the same. No other cytokine/peptide/hormone can claim this and it strongly suggests how important GDF11 is to life!
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Lifespan is programmed by natural selection based on a species resources, predation and the stability of their environment.